Alcoholism treatment: generic Antabuse (Disulfiram)

Alcoholism is a disease characterized by psychological and physical dependence on alcohol. A sick person loses control over alcohol intake of alcohol and continues to use despite negative consequences for their health and social relations. The oxidation of alcohol in the body produces acetaldehyde, a toxic substance that causes the development of chronic toxicity in the body. Excessively drinking, leads to metabolic disorders in the body, destruction of the liver, heart, and kidneys. Very sensitive to the effects of the alcohol nervous system. The signs of nervous system disorders include tremors, night sweats, insomnia, general irritability, weakness. Chronic alcoholism leads to mental illness. In addition, the risk of suicide among patients with alcoholism increased tenfold. About half of the murders as committed under the influence of alcohol.

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The main features of the transition to drinking alcohol are the absence of a protective response vomiting when taking large doses of alcohol and loss of control over the quantity of alcohol consumed. There are several stages of alcoholism. As the disease increases alcohol dependence, and an opportunity to get rid of the alcohol decreases. You may experience alcoholic psychosis and hallucinations, there is a significant degradation of the individual patient with irreversible changes in the psyche. A man drinks alcohol almost every day. There are irreversible lesions of internal organs, usually liver cirrhosis.

One of the most effective treatments for alcoholism is a method of sensitizing therapy. Its purpose is to suppress the craving for alcohol and creating conditions for the forced abstinence from alcohol. The patient was prescribed the drug Antabuse, which in itself is harmless. However, when ingested alcohol, the reaction of interaction, the consequences of which can be very serious and unpredictable consequences for the patient. The reaction to the drug in the body occurs only in the case of alcohol. This therapy helps to get rid of alcohol addiction for most patients.

So, what is Antabuse? Alcoholism is more perfidious than you can imagine. Often, people do not notice how their inoffensive habit of having one or two glasses of favorite alcoholic drink with friends becomes a real addiction. Some people are subject to a bigger risk, due to their physical, emotional, or hereditary peculiarities. But do not let down your weapons, as there is really a way out of this situation. Alcoholism is an awful disease and that is why you need a powerful and effective weapon against it. Disulfiram (the brand name – Antabuse) is a drug produced by the company known as Odyssey Pharmaceuticals. Disulfiram (Antabuse) is used to treat alcoholism, taking it one will be able to overcome his drinking problems. A similar therapeutic effect is achieved with Revia, but you must understand the difference between these medicines.

What is Antabuse history?

The history of Disulfiram began in the first half of the 20th century when it began to be used for the vulcanization of rubber. They noticed that people who worked in the shops where vulcanization took place had an acute adverse reaction to alcohol intake. In 1948, Eric Jacobsen, Jens Hald, and Kenneth Ferguson, employees of Danish Medicinalco pharmaceutical company, studied Disulfiram as a potential anti-worm drug. In this capacity, it did not live up to expectations, but a remarkable case occurred during the study. Jacobsen and his colleagues took a dose of this drug inside to confirm Disulfiram’s safety. They went to dinner and washed down their lunch with beer. Then they felt unwell with redness of the face, increased heart rate, and breathing. Since earlier beer did not produce such an effect on them, they guessed that it was Disulfiram. The research was continued, and already in 1949, Disulfiram began to be used to treat alcoholism.

Disulfiram is used to treat those who suffer from a severe addiction to alcohol. Disulfiram is used together with other forms of treatment such as counseling to provide the desired results. There are also currently researching its use in other areas. Among these include a treatment for cocaine addiction. This is because it has been shown to prevent the breakdown of dopamine which is the stimulant found in cocaine. Disulfiram has also been shown to have what is known as antiprotozoal properties. This is an ability to fight many infections caused by protozoa. Disulfiram is also being studied for use as a cancer treatment.

How Disulfiram works

When you consume alcohol it is first broken down into what is known as acetaldehyde. This then is carried by the blood to the liver which further breaks it down by the action of an enzyme known as aldehyde dehydrogenase. The active ingredient in Disulfiram belongs to a group of chemicals known as aldehyde dehydrogenase inhibitors. These will prevent the enzyme in the liver from breaking acetaldehyde further. This will lead to an accumulation of acetaldehyde in the bloodstream. The increased levels of these in the blood lead to unpleasant side effects such as an increased heartbeat, flushing, and dizziness as there is reduced blood pressure. Other Disulfiram reactions may include nausea that is accompanied by vomiting, you may get headaches, palpitations, and/or shortness of breath. This usually occurs a few minutes after drinking and the effects may several hours subside.

Antabuse dosage

The medicine is taken orally with a glass of water. It should be taken strictly as per the prescriptions and alcohol should be given a wide berth while under this medicine. Overdosing and underdosing will lead to inefficiency and as a rule of the thumb, the medicine is not sharable. A single dose is usually enough. This information is professional, and the drug is advertised for what it is.

The Disulfiram tablet is specifically important, but a patient with heart, kidney, liver, and psychotic diseases as well as brain damage and diabetes should consult the doctor prior to taking this medicine. Pregnant and breast-feeding mothers should do the same. Obviously, if one is alcoholic and also allergic to Disulfiram, he or she will need special attention from a doctor.

Before treatment the patient carefully examined. In the absence of contraindications explain the principal of patient care and caution on the dangers of alcohol during treatment. It recommends taking Antabuse orally at 250-500 mg 1-2 times daily at first. After 8-10 days, conducting a sample of alcohol in patients, with a low dose of alcohol increases the reaction at 10-20 ml. In the future, you can use the maintenance dose of 125-250 mg/day for 1-3 years.

Disulfiram reaction and possible side effects

Antabuse is made use of to supply that inspiration not to consume and in situations, the client fails to avoid alcoholic beverages could create consequences. Antabuse induces quite undesirable wellness results if the patient drinks alcohol while under its effects, which can occasionally lead to cardio collapse, respiratory misery. In cases of small amounts of liquor consumed, Antabuse often causes unfamiliarity, arrhythmias, flushing, thirst, reduced blood stress, quick heartbeats, dizziness, breast discomfort, or queasiness. This medication must be used just by individuals well-informed of the results it can have. Due to the fact that the communications Antabuse could have with the alcohol you consume, a person unaware of those impacts has a high danger of developing some health complications. Antabuse works by obstructing the means your physical body metabolizes liquor and ought to be taken regularly for the very same level of the medication to be in your bloodstream. Antabuse ought to be taken just after you have actually reviewed any type of clinical disorders you likewise have, such as diabetes, mental illness, liver condition, mental retardation, kidney disease, thyroid gland illness, or seizure disorder. For instance there is any sort of various other ones you really feel like reviewing, do to be reluctant to do that.

You need to be aware of products like colognes, lacquers, tonics, paint thinners, aftershaves, cough and cold medicines, antiseptics, mouthwashes, solvents, sauces, vinegar, perfumes or stains may also cause reactions with Antabuse because of the alcohol content they may have.

Where to buy?

You are now experiencing an extremely important concern: which of both ways of obtaining your Antabuse are you visiting choose? On the one hand, there is a regional drug store that you could go to when you have a prescription from your doctor, on the various other hands, there are hundreds of on-line pharmacies that offer common Antabuse and are delighted to see you even at night, so much excited to aid you to discover whatever you are looking for. With their help, you will quickly be able to discover every little thing you need for a lot less cash, yet to be able to do that you have to go for on-line buying. Nevertheless, this is the most inexpensive method of obtaining your drugs. You ought to really not pay excessive focus on things they claim concerning common Antabuse not being rather the appropriate kind of medicine, due to the fact that common medicines are all the medicines around, it’s simply that some universal drugs are made by a specific supplier that gives them the trademark name. The label is the only distinction between them if we are discussing the technical facets, and the price is something they definitely do not have in typical if we are talking regarding cash. Online pharmacies offer higher-top quality generic Antabuse, however, you certainly wish to obtain a lot more from your buying encounter. You constantly wish to see to it you get the most out of your buying by paying much less, getting Antabuse delivered quickly, and always being entirely confidential when the drug is provided.


Dr. Peter Hoffman, addict specialist

One of the most successful strategies for the treatment of alcoholism in my medical practice is the use of drugs that cause nausea and discomfort when consuming alcohol. The main purpose of using these drugs is to develop a distaste for alcohol in my patients. The action of Disulfiram due to the ability to disrupt the metabolism of alcohol. After ingestion, Antabuse is converted into substances that are involved in the metabolism of ethanol. This leads to increased concentrations of metabolites of ethanol, which causes negative experience nausea, vomiting, dizziness, tachycardia, drop in blood pressure, which makes unpleasant alcohol after taking Antabuse. Thus, Antabuse produces an aversion to alcohol and allows for complete intolerance of alcohol. After treatment, 70% of my patients stop drinking alcohol.

Dora, 41 y.o.

I have taken Antabuse a year ago. Worked a miracle but then I stopped taking it and went back to my old ways. I’m bulimic so too much alcohol with no food in my system equals disaster for me.  I just took my first pill today since a year ago and am determined to change my life.  My son has seen me too drunk too many times now. It’s got to stop and it’s up to me. Thank you!!!

George, 33 y.o.

I called my psychiatrist this morning and asked him for Antabuse, and he said no problem and sent in the referral for the prescription to my pharmacy. I’m just lucky and blessed to have a great doctor who’s been doing his job for over 45 years. He has prescribed Antabuse 50 mg. I had a very good experience. It does work pretty quickly. For me, the preoccupation with drinking and the strong compulsion to buy alcohol diminished very quickly. When I did drink, I didn’t get as much out of it as I used to. One beer, and I’m done usually. I was very skeptical of the efficacy of the drug, but I recommend it to anyone who wants to reclaim their life.

Evan, 58 y.o.

Been on Disulfiram for almost 3 years now. It saved my life in some ways frankly. I might have 3-5 drinks/month now and each time I kind of regret even consuming 2 drinks in a night, and the taste of alcohol straight up grosses me out at times…of any kind.

I never even want to over drink anymore is the point. I say all this for people to know what it’s like for someone that was a pretty bad alcoholic for years and years and could honestly say I could never have a drink again and be fine. There are very few things I would miss. This method works for ‘most’. Do some good research is all…like anything.

Nicolas, 25 y.o.

I took Antabuse and I couldn’t even use deodorant with alcohol in it. I did it by accident a few times and aside from the disgusting sick feeling, it made my blood feel like a sponge. A weird thing to try to explain. Certainly knew if I’d accidentally put alcohol on my skin shortly after. A good drug that kept me sober for a year and afterward I relapsed. That was a long time ago. I’m 6 years 4 months sober now!


Antabuse worked for me for one year.  It did not sort the underlying problem but it broke a habit and kept me sober for a year. I tried once to test it and after that never again. So for me, it was good.

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